Marma
Points of a Human Body.
Human
Physiology in Ayurveda
‘Śarīra
Vicaya’ is the Ayurvedic term that represents both Anatomy and Physiology.
‘Vicaya’ means the special or detailed knowledge. As per Caraka, the detailed
knowledge of normal human body is helpful to understand the factors influencing
health and therefore such knowledge is widely appreciated by experts. (Ca.Śā.
6/3).
Theory
of ‘Tridoṣa’: A Physiological Perspective
This
theory forms the basis of Ayurvedic physiology, pathology and pharmacology. Though,
the term ‘Doṣa’ means ‘the disturbing factor’, it has got definite
physiologicalimportance in normal state. Basically three ‘Dosas’- ‘Vāta’,
‘Pitta’ and ‘Kapha’- are responsible for maintenance of homeostasis in the
body, and health is nothing but a state of equilibrium of these ‘Tridosas’.
Disease is manifested as a result of disturbance in the state of equilibrium
among these ‘Dosas’.
The
concept of ‘Tridosa’ is basically a theory and any single substance or
structure in the body can not represent a ‘Dosa’. Terms like ‘Pittavarga’ and
‘Kaphavarga’ have been used in some textbooks and such usage indicates that
these (‘Vāta’-‘Pitta’-‘Kapha’) were perceived to be three groups of
physiologically similar substances. ‘Vāta’ is responsible for all movements and
it is the initiating and controlling factor. ‘Pitta’ performs the activities
like digestion, metabolism, production of heat and that is why it is called
‘Agni’ meaning ‘Fire’. ‘Kapha’ performs the functions like protection,
strength,
stability
and resistance.
As
Ayurveda is based on functional understanding of body, the different entities representing
‘Tridosas’ at each level of organization can be assumed by analyzing these functions.
In generalized terms, the nervous, endocrine and immune mechanisms can be equated
to ‘Vāta’, ‘Pitta’ and ‘Kapha’ respectively.
Homeostasis:
Imbalance
in the state of bodily-tissues is known as ‘Disease’ and equilibrium is called
‘Health’. (Ca.Sū. 9/3, Ca. Śā. 6/18). Aim of this entire stream of science
(Ayurveda) is to re-establish the state of equilibrium among different tissues
(Ca. Sū. 1/53). ‘Dhātusāmya’ is the term
given for homeostasis in Ayurveda. In Suśruta’s view, the life on this universe
is maintained because of three opposing factors known as Sun, Moon and the Air.
The Sun exerts a drying effect on earth whereas the moon is coolant and
strengthening in nature. Air brings about all types of movements. In exactly
similar manner, the body is sustained
by three opposing factors called ‘Vāta’, ‘Pitta’ and ‘Kapha’ (Su. Sū. 21/8).
Concept
of a Cell: Caraka has explained that the body parts
can be divided and re-divided into innumerable individual components called
‘Paramānus’. These are innumerable because of their huge number, highly minute
structure and limited perceptive ability of sense organs.(Ca. Śā. 7/17). This
statement indicates that there existed a concept of minute and numerous individual
living units in the body. Today we call such microscopic units by the name
‘Cell’.
‘Anu
Srotas’ is another such very similar term, probably indicative of a cell. Some
scholars even held the view that the living body is nothing but the resultant
of aggregation of such innumerable ‘Srotāmsi’. (Ca.Vi. 5/4). ‘Srotāmsi’ is the
plural form of ‘Srotas’. The term ‘Srotas’ means an individual ‘Cell’ - ‘Anu
Srotas’ and also an individual ‘Organ System’ -
‘Sthūula
Srotas’. A tissue is a group of structurally and functionally similar cells.
‘Srotāmsi’ are structurally similar to their corresponding tissues. Also, each
‘Srotas’ is functionally (Metabolically) related to its corresponding tissue.
Basic
Tissues: Plasma and lymph (‘Rasa’), blood cells (‘Rakta’),
muscular and general connective
tissues (‘Māmsa’), body-lipids including adipose tissue (‘Meda’), tissues
resisting easy degradation - like bones (‘Asthi’), bone marrow and nervous
tissue (‘Majjā’) and tissues responsible for reproductive functions (‘Śukra’)
are the basic tissues from which the body is formed. (A.H. Sū.1/13).
Tissues
producing breast-milk (Stanya), female reproductive tissues (Ārtava),
‘Kandarā’
(tendons), Sirā (blood vessels), ‘Vasā’ (muscle fat), six layers of skin and
‘Snāyus’ (sinews) are the ‘Upadhātus’ (subsidiary tissues). Tissues producing
breast-milk and female reproductive tissues are Upadhātus of ‘Rasa’. ‘Kandarā’
and ‘Sirā’ are Upadhātus of ‘Rakta’.‘Vasā’ and skin are Upadhātus of ‘Māmsa’.
‘Snāyu’ is the Upadhātu of ‘Medas’. (Ca. Ci.15/17).
Classification
of tissues described in Ayurveda is based on some rational
observations.
For example, ‘Rasa Dhātu’ includes both plasma and lymph (Intravascular fluid).
‘Rakta Dhātu’ mainly stands for RBCs. ‘Māmsa Dhātu’ stands for muscular tissue
in general but also includes general connective tissue and parenchymal and
stromal tissues of different viscera. As ‘coating’ or ‘covering’ is the
function of ‘Māmsa Dhātu’, even epithelial tissue is included under the same.
‘Medo Dhātu’ includes adipose tissue and circulating lipids
of
blood because it is of two types: ‘Baddha’ (bound) and ‘Abaddha’ (free). ‘Asthi
Dhātu’ includes all those structures of the body, which resist easy
degradation. So, teeth and nails also are included under this ‘Dhātu’. ‘Majjā
Dhātu’ stands for everything that fills bony cavities. So, apart from bone
marrow, it also stands for Brain substance because this fills up a cavity
formed by the union of several cranial bones. ‘Śukra Dhātu’ mainly stands for
all hormones of hypothalamo-pituitary-gonadal axis. Supplying the nourishment
(Prīnana), delivery of life-principle (Jīvana), providing covering or coating
(Lepa), providing lubrication (Sneha), giving mechanical support (Dhārana),
filling-in the (bony) cavities (Pūrana) and reproduction (Garbhotpāda) - are
the most
important functions of these seven ‘Dhātus’ respectively. (A.H. Sū. 11/4).
Physiology
of Nervous System
All
movements are due to ‘Vāta’ and that is why it is called the ‘Prāna’ of all
living beings. (Ca. Sū. 18/118). So, ‘Prānavaha Srotas’ stands for the system
concerned with the activities of ‘Vāta’. ‘Prānavaha Srotas’ stands for the
system that transports a specific type of
‘Vāta’ called ‘Prāna Vāta’. This is a special Srotas meant for a special
type of ‘Vāta’ (Cakrapāni on Ca.Vi. 5/8).
Brain
and Brainstem: ‘Śiras’ (Head) is the region where all
‘Prānas’ (most vital entities) are situated and all sensory and motor
activities are controlled from. That is why ‘Head’ is called the ‘Most
important organ’ among all parts of the body (Ca. Sū. 17/12). It is described
that all sensory and motor organs along with their ‘Prāanavaha Srotāmsi’, are
connected to the brain in a fashion that is similar to the connections between
the sunrays and the Sun. (Ca. Si. 9/4).
Bhela
has explained that the mind is situated in between the head and palate. The
efficiency of mind is beyond any other
sensory or motor organ (Bh.Ci. 8/2-3).
Reflexes:
Caraka
has opined that one should not suppress the natural urges related to micturition,
defecation, ejaculation, flatus, vomiting, sneezing, eructation, yawning,
hunger, thirst, tears, sleep and also dyspnoea developed after exertion (Ca.
Sū. 7/3-4). It should be noted that one or the other reflex is involved in all
these activities. So, the term ‘Vega’ stands almost equivalent to reflex.
Concept
of ‘Vāta’: All functions of nervous system in human
body are represented through ‘Vāta’ in Ayurveda. In general, the functions
ascribed to ‘Vāta’ are: Control and coordination of different parts of the
body, initiation of all movements, regulation of psychological processes,
initiation of all activities of sense organs, transmission of different sensations,
production of speech, secreto- motor functions in the gut, expulsion of wastes from
the body and control of respiration (Ca.Sū.12/8). ‘Vāta’ is divided into five
sub types –‘Prāna’, ‘Udāna’, ‘Vyāna’, ‘Samāna’ and ‘Apāna’.
‘Prāna
Vāta’: This is situated in head and is responsible for the
control over intellectual functions, cardiovascular functions, sense organs,
psychological activities, respiration, and reflex activities like sneezing,
belching and deglutition (A.H.Sū. 12/5). Based on this subtype of ‘Vāta’,
‘Prānavaha Srotas’ has derived its name.
‘Udāna
Vāta’: Its active site is chest region. It is basically
responsible for production of speech. The effort and strength required for
speech are also the functions of ‘Udāna’. It also helps in recall of vocabulary
required for well-articulated speech (A.H.Sū. 12/5).
‘Vyāna
Vāta’: The active site of ‘Vyāna Vāta’ is Heart. It makes
the circulation of blood possible by controlling the heart. Vyana makes ‘Rasa’
(the intravascular fluid including plasma and lymph) to get forcefully ejected
out of the heart and makes it circulate throughout the body (Ca. Ci. 15/36).
So, sympathetic and parasympathetic control of heart is indicated by ‘Vyāna
Vāta’. Some authors have ascribed the functions of somatic nervous system also
to
‘Vyāna
Vāta’ as movements like flexion, extension, opening and closure of eyelids have
been said to be under its control (Ca. Ci. 28/9).
‘Samāna
Vāta’: Active site of ‘Samāna’ is adjacent to gastro
intestinal tract. It performs the functions like reception of food, its
digestion through the activation of ‘Agni’, its division into useful and waste
parts and its onward propulsion (A.H. Sū. 12/8). All these functions are either
those of parasympathetic nerves supplying the gut or those of enteric nervous
system.
‘Apāna
Vāta’: This is active in pelvic region. ‘Apāna’ governs
physiological processes like micturition, defecation, ejaculation, menstruation
and parturition (A.H.Sū.12/9). Autonomic nervous system has got a definite role
in most of these activities.
Physiology
of Gastro Intestinal Tract
‘Annavaha
Srotas’ has got its roots situated in stomach, especially on its left side.
‘Purīshavaha Srotas’ has got its roots in large intestine, especially at rectum
(Ca.Vi. 5/8). ‘Annavaha Srotas’ and ‘Purīsavaha Srotas’ together form the
complete gastrointestinal tract. ‘Annavaha Srotas’ includes upper and middle
part of the gut whereas ‘Purīsavaha Srotas’ is lower GIT.
Deglutition,
Mucous secretion and Secretion of Enzymes: The food is
brought towards the gut through ‘Prāna Vāta’. There, various fluids making its
bonds loosen, act on it. Also, the food is softened here. Then the ‘Samāna
Vāta’ stimulates ‘Jatharāgni’. This ‘Agni’ finally digests the food (Ca.Ci.15/6,
7). After the food reaches stomach, several digestive juices act on it. Gastric
juice, pancreatic juice, and enterocytes in the intestines - all contain
important
digestive
enzymes and act on food. Secretion of these enzymes is mostly under the control
of parasympathetic nerves and intrinsic enteric nervous system. This is how
‘Samāna Vāta’ stimulates ‘Agni’.
Digestion
in Upper GIT: First stage of digestion is called
‘Madhura Avasthāpāka’. This takes place in the stomach. During this stage,
there occurs the release of froth-like ‘Kapha’ (Ca. Ci.15/9). Salivary juice
and mucous secreted in the stomach serve many protective functions but do not
directly participate in the actual process of digestion. These are therefore indicative
of froth-like ‘Kapha’, which is ‘Malarūpī’ in nature.
Digestion
in Small Intestine: ‘Pitta’ that is present in between
stomach and large intestine is called ‘Pācaka Pitta’. Though made up of five
basic elements, it is dominant in fire principle. So, it is devoid of liquidity
and is called ‘Anala’ (‘Agni’). This digests the food and splits it into
essential nutrient part called ‘Sāra’ and waste part called ‘Kitta’ (A.H. Sū.
12/10-12). The ‘Pācaka Pitta’ is directly responsible for digestion of the food
and therefore stands for all
amylolytic,
proteolytic, lipolytic and nucleic acid splitting enzymes. Gastrointestinal hormones
like gastrin, secretin, cholecystokinin etc. also must be regarded as the representatives
of ‘Pācaka Pitta’. ‘Sāra’ (Nutrient) portion separated at this stage gets absorbed
and thereafter it is called ‘Rasa Dhātu’.
Release
of Bile Juice: In the small intestine, ‘Accha Pitta’
(Bile) is released (Ca. Ci. 15/10) during the second stage of digestion. This stage
is called ‘Amla’ ‘Avasthāpāka’ and during this phase, the bile juice and
pancreatic juices are secreted into the duodenum. The bile is liquid and it is
called the ‘Accha Pitta’. ‘Accha’ means ‘liquid in form’. This is the ‘Mala’ of
‘Rakta’. Bilirubin is a derivative of hemoglobin metabolism and represents this
‘Accha Pitta’.
Factors
influencing Digestion: Digestion of food depends on
following important factors: optimum temperature, ‘Vāyu’, fluid medium,
lubricating substances, time and appropriate administration. ‘Vāyu’ helps in
movement of food in the gut. Fluids make the food particles easily breakable.
Lubricating substances make the food softer. Time factor makes sure that the
food is completely and properly digested. Along with all these factors, if the administration
also is proper, the resultant digested material will be capable of maintaining ‘Dhātusāmya’(Ca.
Śā. 6/14,15).
Absorption
and distribution of Digested Material: After the completion of
the digestive process, the digested material reaches all parts of the body
through the vessels called ‘Dhamanīs’ (Ca.Vi. 2/18).
Large
Intestine: After the nutrients are absorbed from
the small intestine, the remaining undigested portion of food reaches the large
intestine. Here, it experiences the drying effect of ‘Agni’ and there is
formation of solid fecal matter along with the release of ‘Vāta’ of ‘Katu’
(pungent) nature. This stage is the third stage of digestion and is called ‘Katu
Avasthāpāka’ (Ca. Ci. 15/9-11). In the large intestine, except for absorption
of water and some electrolytes, no digestive activity takes place. But this
absorption of water makes the remaining undigested material hard and this
material is called feces. Due to the activity of
bacterial
flora, some pungent gases like methane and ammonia are also produced here.
These represent ‘Katu’ nature of ‘Vāta’ released during this stage.
Physiology
of Respiratory System
Functions
in General: ‘Prāna Vāta’ situated at ‘Nābhi’, comes
out through the throat to consume a nectar-like substance called
‘Visnupadāmrta’ from the atmosphere. After consuming this nectar of
atmosphere, it re-enters the body speedily and nourishes the ‘Jīva’ (Śā. Pū.
5/51). Though the site of ‘Prāna Vāta’ is described to be ‘head’ in all
earlier textbooks, Śārnńgadhara has described it to be ‘Nābhi’ in this
reference. ‘Nābhi’, in Samskrta language, just means ‘a center’. So, this is
indicative of a particular center in the head. ‘Raktam jīva iti sthitihi’ is
the opinion of Suśruta and this means that the terms ‘Jīva’ and ‘Rakta’ are
synonyms. So, when translated with this background, the above verse gives the following
meaning: “Because of the activity of ‘Prāna Vāta’ that is situated in brain, a
nectar like substance is consumed through the act of respiration. This
substance in turn, nourishes the ‘Jīva’ (Blood).” This nectar-like substance
must be oxygen. Nervous control of respiration and transportation of oxygen
through blood also can be inferred from this reference.
Lung
– Phupphusa: On the left inferior aspect of the
heart, ‘Plīhā’ (spleen) is situated and on its left side there is ‘Phupphusa’
(Left lung). On right side, the corresponding organs situated are ‘Yakrt’ (Liver)
and ‘Kloma’ (Right lung) respectively (Su. Śā. 4/31). Suśruta has used two
different terms to mean left and right lungs- ‘Phupphusa’ for left lung and
‘Kloma’ for right lung. This conclusion is drawn because of the fact that the
term ‘Phupphusa’ has not
been
used in its plural form.
Physiology
of Cardiovascular System
Cardiovascular
system (‘Rasavaha Srotas’) originates at heart and ten great vessels attached to
it (Ca. Vi. 5/7). Ten vessels may be indicating two venae cavae (superior and
inferior), one aorta, four pulmonary veins, one pulmonary trunk and two
coronary arteries- as all these are directly connected to heart.
Contents
of Cardiovascular Compartment: The term ‘Rasa’ stands
for all circulating fluids in the body including the fluid portion of blood
(Cakrapāni on Ca.Ci. 15/36). ‘Rasa’ is also the minutest and essential
fraction of properly digested food. Heart is the site for this ‘Rasa’ (Su. Sū.
14/3). This ‘Rasa’ circulates in the body along with ‘Rakta’ (Ātañkadarpana on
Mā. Ni. 33/4). Ten great blood vessels connected to heart carry the ‘Rasātmaka
Ojas’, on which the whole life process is dependent (A.H. Śā. 3/18). From the
above references it is
clear
that three major substances circulate in the cardiovascular compartment- the
first one is ‘Rasa’- the liquid nutrient portion of blood (Plasma); the second
substance is ‘Rakta’, the oxygen- carrying red material (RBCs); and the third
one is ‘Ojas’- the white substance that is responsible for immunity (WBCs).
Autonomic
Control of Heart: ‘Vyāna Vāta’ is responsible for the
forceful ejection of ‘Rasa Dhātu’ from the heart that later circulates all over
the body to perform its function of providing nutrition (Ca. Ci. 15/36 and Su.
Ni. 1/17).
Cardio
Vascular System is a Closed Circuit: ‘Rasa’ is ejected out
of the heart. It is then carried to all parts of the body. The blood vessels
called ‘Sirās’ bring it back to the heart (Bh.Sū. 21).
Structure
and Functioning of Heart: Appearance of heart is similar to
that of an inverted bud of lotus. When the individual is ‘awake’, this lotus
blossoms forth and when he is ‘asleep’, it closes up (Su. Śā. 4/32). The narrow
apex of the heart is directed downwards and broader base is directed upwards
when the individual is standing. This observation is reflected in this
explanation saying that the heart looks like an inverted bud of lotus. To indicate
‘life’ and ‘death’, the terms ‘awake’ and ‘asleep’ are often used in Sanskrit
literature. So, meaning of this statement is that functioning of heart
continues till the death of an
individual.
Mean
Flow Velocity of Blood: The manner, in which ‘Rasa’ moves
all over the body, is exactly similar to the manner in which sound, fire and
water move (Su.Sū. 4/16). As per the view of different commentators, velocity
with which sound moves is greater than that of fire and the velocity of fire is
greater than that of water. Therefore, it can be said that this is the explanation
of the mean flow velocity of blood which is maximum in the aorta and minimum in
the capillaries. This is because the smallest cross-sectional area, which
receives the entire output of the blood from heart, is aorta and accordingly,
the mean flow velocity is highest in that vessel.
Theories
for Microcirculation
‘Kedārī
– Kulyā Nyāya’: This theory describes different tissues
as different fields, which receive water through different channels, which in
turn, are connected to a big reservoir of water. Nutrient fluid in this case is
‘Rasa’, which nourishes all tissues through specific channels. This theory
explains the importance of pressure-gradient, which determines the flow of
fluid into the tissue-spaces as this is similar to the movement of water in the
direction
of
gravitational force in the above example (Cakrapāni on Ca.Ci. 15/16-17).
‘Khale-
Kapota Nyāya’: This theory explains the auto-regulation
of blood flow by tissuefactors. Blood flow to each tissue is regulated
depending on the metabolic needs of the particular tissue. The example given to
explain this theory is that of different pigeons, picking up the grains from
the same field and then returning to their original places. Here, the choice regarding
the amount of grains purely depends on the need of the individual pigeon (Cakrapāni
on Ca.Ci. 15/16-17).
Physiology
of Hemopoietic System
The
roots of Hemopoietic system are explained to be Liver and Spleen (Ca.Vi. 5/8). Role
of liver and spleen in the functioning of hemopoietic system is very important.
RBC synthesis occurs in liver and spleen in between 3rd and 5th month of
intrauterine life. Liver stores some important hemopoietic factors like Vitamin
B-12, folic acid and iron. It produces many clotting factors also. Cells of
monocyte-macrophage system destroy RBCs in the spleen after they complete their
life span.
Role
of Bone Marrow: In the cavities of larger bones ‘Majjā’
is present whereas in the smaller ones it is ‘Sarakta Meda’(Su. Śā. 4/10). This
‘Sarakta Meda’ is indicative of Red-bone marrow.
Formation
of Bilirubin: Byproduct of metabolism of ‘Rakta’ is
‘Pitta’.(Ca. Ci. 15/18). This ‘Pitta’ is Bilirubin, the product of hemoglobin
metabolism. This is formed in the monocytemacrophage system, mainly in the
spleen.
Hyperbilirubinemia:
When
the ‘Pitta’ exceeds its normal levels, there is manifestation of symptoms like
yellowish discoloration of feces, urine, eyes and skin (A.H. Sū. 11/7). When the
total serum bilirubin level exceeds 2mg/dl, usually there is manifestation of
clinical jaundice.
Endocrinology
and Metabolism
Normal
vision, normal appetite, normal thirst, normal body temperature, normal softness
of body parts, normal complexion, normal nourishment and normal intellectual functions-
are all the functions of normal ‘Pitta’ (Ca.Sū. 18/50). These parameters are
good indicators of many of metabolic activities. For example, impaired Vitamin
A metabolism leads to problems in vision. In hyperthyroidism there is excessive
hunger and increased body temperature. In diabetes mellitus there is polydypsia
and polyphagia. In hypothyroidism, normal softness of the skin and subcutaneous
tissue is lost. In Addison’s disease the excessive
pigmentation leads to alteration in the complexion. In Cretinism, the mental
growth is retarded.
Intermediary
Metabolism: The five ‘Agnis’ viz., ‘Bhaumāgni’,
‘Āpyāgni’, ‘Āgneyāgni’,‘Vāyavyāgni’ and ‘Nābha sāgni’ are the causative factors
for the metabolism of five groups of respective ingredients of the food.
Normally, the specific tissues are nourished from those ingredients of food
which are similar to the respective tissues in their composition (Ca. Ci. 15/
13-14). The function of ‘Bhūtāgnis’ is to metabolize the ingredients of food
and to ‘sort them out’ into five groups depending on the predominance of
particular ‘Mahābhūta’. These functions of ‘Bhūtāgnis’ can be explained through
the functions of liver. Basically, whatever is digested and absorbed has to
reach liver first and metabolic interconversion of the substances occurs there.
For example, plant-derived amino acids can be used to synthesize human
proteins, glucose can be converted into glycogen or in to fat, amino acids can
be converted into glucose – and so on. ‘Sorting out’ of different substances
occurs in liver and that is the function of ‘Bhūtāgnis’ too. After the
digestion in gastro intestinal tract is over, the ingredients of food (‘Rasas’)
undergo metabolism once again. This metabolic end- product is called
‘Vipāka’(A.H. Sū. 9/20). This indicates that ‘Vipāka’ is the end product of the
action of ‘Bhūtāgnis’. In other words to say, ‘Bhūtāgnipāka’ itself produces
‘Vipāka’ and therefore, ‘Vipāka’ in general, stands for intermediary
metabolism.
Metabolism
at the Tissue-Level: Each tissue derives its nutrition
through the activity of so called ‘Dhātvagni’. Metabolism at tissue level is
dependent on these ‘Dhātvagnis’. Some part of the tissue becomes supportive
whereas some part becomes waste after the metabolism at this level (Ca. Ci.
15/15).
Different
Metabolic Pathways at Cellular level- ‘Ksīra- Dadhi Nyāya’:
This theory speaks of transformation of one substance into another in a
particular order through the activity of respective ‘Dhātvagnis’. The example
given to state this theory is that of transformation of milk into curd, curd
into butter and butter into ghee in the particular order (Cakrapāni on Ca. Ci.
15/16-17). All metabolic pathways like Glycolytic pathway, Kreb’c TCA cyce, β-
oxidation pathway, Urea cycle, Gluconeogenesis etc. could be the examples for
this
type of transformations with the involvement of their specific enzymes.
Metabolic
State of a Tissue: ‘Jatharāgni’, though is situated in its
own site, has its fractions situated at the tissues. If these fractions become
over active, there will be ‘Ksaya’ (Catabolism) of ‘Dhātu’ and if they become
depressed, there will be abnormal ‘Vrddhi’ of ‘Dhātu’ (A. H. Sū. 11/34). In
fact, several classical hemocrine hormones determine the metabolic state of a
tissue. For example, many amino acids circulating in the blood stream are taken
up by muscles and they are utilized to synthesize muscle proteins under the
influence of thyroxin, growth hormone, insulin and testosterone. So, these
hormones can be grouped under ‘Māmsa Dhātvagni’. If thyroid hormone levels
increase in the blood, there is muscle wasting and loss of weight due to
‘Māmsa Ksaya’. Similarly, Calcitonin, parathormone and Vitamin D3 can be
included under ‘Asthidhātvagni’. In hyper parathyroidism, osteoporosis or ‘Asthiksaya’
is evident.
Physiological
Effects of Normal Metabolism: At the end of
‘Bhūtāgnipāka’, three groups of metabolites are formed: ‘Madhura’, ‘Amla’ and
‘Katu’. ‘Guru’ (Heavy) is another name for ‘Madhura’ whereas ‘Laghu’ (Light)
includes remaining two i.e., ‘Amla’ and ‘Katu’. These groups are called
‘Vipākas’. ‘Madhura Vipāka’ promotes the synthesis of reproductive factor
and
promotes the excretion of feces and urine. ‘Amla Vipāka’ opposes the formation
of reproductive factor and promotes the excretion of urine and feces. ‘Katu
Vipāka’, on the other hand, opposes the synthesis of reproductive factor and
causes retention of urine and feces. Effects of ‘Vipāka’ on the formation of
‘Dosas’ are as follows: ‘Madhura Vipāka’ promotes ‘Kapha’, ‘Amla Vipāka’
promotes ‘Pitta’ and ‘Katu Vipāka’ promotes the formation of ‘Vāta’(Ca. Sū.
26/61,62). Effects of this stage of metabolism may be of manifold. Some
products may be used for tissue synthesis whereas the others may be used for the
purpose of energy. Anabolic effects may be called ‘Guru’ and catabolic ones,
‘Laghu’. Again, ‘Dosas’ synthesized here are of ‘Dhāturūpi’ type (‘Malarūpi Dosas’
are formed during ‘Avasthāpāka’).
Importance
of Normal Metabolism: ‘Agni’ itself is present in the
body in the form of Pitta. When it is normal, it performs the functions like
maintenance of normal digestion, normal vision, normal body temperature, normal
complexion, valor, happiness and nutrition. When it is abnormal, all these
functions also will be abnormal (Ca.Sū. 12/11). Other functions of endocrine
system are described under the functions of ‘Pitta’. Concept of ‘Pitta’: ‘Pitta’
includes all those factors responsible for digestion and metabolism. For all
practical purposes, ‘Agni’ & ‘Pitta’ are to be considered as identical entities
(Su. Su. 21/9, Ca.Sū. 12/11).
‘Pācaka
Pitta’: ‘Pācaka Pitta’ is equivalent to ‘Jatharāgni’ (A.H.
Sū. 12/11). As its functions suggest, all enzymes responsible for digestion
along with all gastrointestinal hormones and all local hormones of G.I.T. are
to be included in it.
‘Rañjaka
Pitta’: It is responsible for synthesis of ‘Rakta’. It is
situated in stomach (‘Amāśaya’) according to Vāgbhata and the sites are liver
and spleen according to Suśruta. Gastric intrinsic factor is the best candidate
to represent Vāgbhata’ s view, as it is required for the absorption of Vitamin
B12, which in turn is needed for DNA synthesis of RBC precursors in bone
marrow.
‘Bhrājaka
Pitta’: As is known, pigmentation of skin is under the
control of some hormones like ACTH & MSH from anterior pituitary. Some
enzymes in the skin responsible for the metabolism of certain drugs applied
topically also can be considered under ‘Bhrājaka Pitta’ along with the hormones
controlling pigmentation.
‘Sādhaka
Pitta’: All functions ascribed to this ‘Pitta’are of
cerebrum, limbic system, hypothalamus and other CNS structures. For motivation
and other psychosocial behaviors Norepinephrine is a very essential
neurotransmitter in the brain. Incidentally, it also acts on heart as a cardiac
stimulant. During emergency situations it is released from adrenal medulla and
it helps for “fight or flight phenomenon”.
‘Alocaka
Pitta’: This is said to be responsible for normal vision.
Photosensitive chemicals in the eye, called Photo-pigments and the whole
process involved in photochemistry of vision can be represented by ‘Alocaka
pitta’. Also, neurotransmitters involved in the visual pathway can be included
under this.
Immune
System
General
Functions: When the Ślesma (Kapha) is in normal
state, it is called ‘Bala’ as well as ‘Ojas’; but when it attains an abnormal
state, it is then called ‘Mala’ (Waste) and ‘Pāpmā’ (Disease) (Ca.Sū. 27/117).
From the above statement it is clear that ‘Bala’, ‘Ojas’ and ‘Kapha’ are
identical entities, at least when ‘Kapha’ is in normal state. When ‘Kapha’ is
in its normal state, it provides compactness, stability, virility, immunity and
resistance (Ca.Sū. 18/51).
Importance:
The
most essential fraction of all bodily tissues is called ‘Ojas’. Eventhough it resides
in the heart, it circulates all over the body to maintain the normal healthy
status of the body. It is ‘Snigdha’ (unctuous) and ‘Somātmaka’ (mild and cool)
in nature. Though predominantly white in colour, it has got some yellowish and
reddish tinge. If this is lost, life also is lost and if this remains intact,
life continues (A. H. Sū. 11/37-38). ‘Ojas’ has been described to exist in
different forms in the body. The fraction of ‘Ojas’ that circulates all over
the body through the cardiovascular system, moves along with ‘Rasa Dhātu’. This
is called ‘Rasātmaka Ojas’. Another form of ‘Ojas’, is present in all tissues
and is called ‘Dhātutejorūpi’. This indicates the immune mechanisms present attissue-level.
A third form of ‘Ojas’ is ‘Śukra mala rūpi’. This enters the fetus to provide protection
to the fetus during intrauterine life. Another form of ‘Ojas’ is described as ‘Jivaśonita
rūpi’ (Hemādri on A.H. Sū 11/37-38).
Classification
of Immunity: Immunity is classified in to three
types: Innate (Sahaja), Acquired (Kālaja) and Artificial (Yukti krta) (Ca.Sū.
11/36).
Factors
Influencing Immunity: The following factors influence the
promotion of immunity: place of birth, time of birth, favorable weather,
excellence of genetic qualities, excellence of properties of food being
consumed, excellence of physique, good ability to tolerate various factors,
excellence of mental status, favorable factors related to nature, youthfulness,
exercise and cheerful attitude (Ca. Śā. 6/13).
Antigen-Exposure
and Host Response: Substances, which have opposite
qualities to those of bodily tissues, (when gain entry into the body) encounter
the opposition by the bodily tissues (Ca. Sū. 26/91). Etiological factors,
‘Dosas’, and ‘Dhātus’ determine the bodily immunity or susceptibility for the
disease. When all the three factors do not support each other or when they are
week due to passage of time, either the disease does not manifest at all or it takes
some time in manifestation or the disease is very mild or all its signs and
symptoms
are not fully manifested. If the situation is opposite to that is mentioned
above, the corresponding results also will be otherwise (Ca. Ni. 4/4). This
means that susceptibility of a particular tissue to any antigenic attack plays
an important role in the manifestation or non manifestation of a disease. At
the same time, the potency of the causative agent also is important. Virulent
strains of infectious agents produce severe symptoms. Along with these two
factors, homeostatic mechanisms also are important. If immune system is
normally functioning,
injurious agents will be tackled effectively.
Concept
of Active and Passive Immunity: Treatment of the
diseases manifested due to the presence of opposing agents in the body, should
be planned either by administering the substances having opposite qualities to
them or by prior sensitization of the body by administering the similar
substances as those of offending agent (Ca. Sū. 26/104). This forms the basis
of active and passive immunity. Prior sensitization of the body with specific
antigen makes one develop active immunity. On the other hand, antibodies can be
procured out of an animal in which active immunity has been already produced,
and can be administered to the individual suffering from the same disease.
Other functions of immune system are described under the functions of ‘Kapha’.
Concept
of ‘Kapha’: Functions of immune system and all such
other protective mechanisms
in the body have been grouped under ‘Kapha’ in Ayurveda. ‘Ojas’ is also closely
related with ‘Kapha’.
‘Avalambaka
Kapha’: Situated in the thorax, ‘Avalambaka Kapha’ protects
the ‘Trika’ and other vital structures like heart, through what is called ‘Ambukarma’.
Other anatomical sites where other types of ‘Kapha’ are situated also are
dependent on this (A.H. Sū. 12/15-16).
‘Trika’
region indicates the meeting point of three bones. As this is present in
thorax, it must be indicating the junction between the sternum and clavicles,
behind which, the thymus gland is situated. ‘Ambu’ means liquid or water. So,
‘Ambukarma’ must be referring to lymphatic drainage.
‘Kledaka
Kapha’: This is present in stomach and it moistens the
ingested food (A.H. Sū. 12/16-17). Mucous secreted in stomach plays important
role in offering protection to mucous membrane of the stomach along with
providing liquid medium for digestive process. Also, Gut Assosiated Lymphoid
Tissue helps in providing protection by preventing the entry of any microbes
through gut. HCl secreted in stomach also provides innate immunity to some
extent.
All
these mechanisms can be explained through ‘Kledaka Kapha’.
‘Bodhaka
Kapha’: This is said to be present in oral cavity and helps
in the perception of taste. Salivary juice secreted in the oral cavity not only
helps in the process of taste perception but also performs some protective
functions. Root of the tongue is the site of ‘Bodhaka Kapha’. Tonsils are the
important lymphoid tissue-containing structures present there.
‘Tarpaka
Kapha’: This sub-type of ‘Kapha’ is present inside the head
and is responsible for the protection and nourishment of sense organs.
Microglia and other similar Glial cells of brain tissue are some of the
important entities, which may represent ‘Tarpaka Kapha’.
‘Ślesaka
Kapha’: This Kapha is present in the bony joints and is
responsible for lubrication and easy movements. Movements are most obvious in
synovial variety of joints and synovial fluid reduces the friction between two
articular bony surfaces. But ‘Slesaka Kapha’ is not only synovial fluid. For
several reasons known and unknown, these joints are the sites of prominent
inflammation in most of the systemic autoimmune diseases like Systemic Sclerosis,
Systemic Lupus Erythematosus and Rheumatoid arthritis. Such involvement must be,
therefore, ascribed to the problems of ‘Ślesaka Kapha’.
Physiology
of Male Reproductive System
The
roots of ‘Śukravaha Srotas’ are the testicles and penis (Ca. Vi. 5/10).
Testicles synthesize the hormone testosterone and also they are the sites of
spermatogenesis. Penis is the male copulatory organ through which the seminal
fluid is deposited in the female reproductive tract. The factor, which is
responsible for the formation of ‘Garbha’ (embryo), is known as ‘Śukra’ (Ca.Śā.
2/4). ‘Śukra’ is distributed all over the body in the same manner in which the
fat in the milk and juice in the sugar cane plant are distributed (Ca.Ci.
2/46). Also, this
is present in males and females. All hormones of hypothalamo-pituitary-gonadal
axis can thus be included under the term ‘Śukra’. In some references, ‘Śukra’
stands for only semen. Fatty portion of ‘Majjā’ forms ‘Śukra’. This ‘Śukra’
comes out of bones through the pores created by ‘Vāyu’ and ‘Ākāśa Mahābhūtas’.
As if the water oozing out of new mud pot, ‘Śukra’ also oozes out of these
pores and then circulates all over the body through ‘Śukravaha Srotāmsi’
(Ca.Ci. 15/32-33). ‘Majjā’ stands for even brain substance. ‘Mastakamajjā’ is
the term given to indicate brain by Dalhana, the commentator of Suśruta Samhitā,
while commenting on Su.Śā.10/42. Hypothalamus secretes GnRH and Hypothalamo-hypophysial
portal system carries this to the anterior pituitary. Anterior pituitary, in response
to GnRH, secretes FSH and LH into the blood stream. These hormones then
circulate all over the body and stimulate ovaries and testicles to secrete
their own hormones.
Ejaculation:
When
the person gets excited because of the sexual urge, determination and romantic
mental attitude, ‘Śukra’ comes out through the urethra (with which the bladder
is connected) as if the melted ghee. This occurs because of the heat produced
by the physical exertion during copulation. The simile given to describe this
process is the flow of water from a place of lower altitude to a place of
higher altitude (Ca.Ci. 15/34-35). Generalized sympathetic stimulation is an
essential feature of sexual activity. Erection requires parasympathetic
stimulation whereas ejaculation is dependent on sympathetic one. Also, ejaculation
is brought about by ‘Apāna Vāta’, which represents the sympathetic activity in this
case.
Physical
properties of Semen: The semen is ‘Snigdha’ (unctuous), dense,
slimy, sweet, non-irritating (mild), and white just like a piece of alum
crystal (Ca.Ci. 30/145-146).
Physiology
of Female Reproductive System
Menstrual
blood (‘Raja’) also is a derivative of ‘Rasa’ only. Menstruation occurs in
females once in every month and lasts for about three days. This process of
menstrual cycle begins at the age of twelve years and stops at about fifty
years of age (Su.Sū. 14/6). During the act of copulation, production of ‘Śukra’
occurs in females also; and it should not be thought that it is of no use in
the process of production of embryo i.e., it is also of definite use (A.S. Śā.1/72).
Features of ‘Rakta’ and ‘Ārtava’ are similar. ‘Ārtava’ is responsible for the production
of embryo (Su. Sū. 15/5). ‘Rakta’ and ‘Ārtava’ are similar functionally. This
is because the function of ‘Rakta’ is to ‘Give life’ (‘Jivana’) and the
function of ‘Ārtava’ also is to give life to a new individual (embryo). So,
‘Ārtava’ means ovum in this context. This ‘Ārtava’, after getting nourished
over the period of a month, enters (the uterus and then) vagina through the
specialized structures called ‘Dhamanis’ meant for the transportation of the
same. ‘Vāta’ is responsible for this movement of ‘Ārtava’(Su.Śā. 3/10). This is
the explanation regarding the process of ovum entering the uterus through the
Fallopian tube. If not fertilized, it is shed off through menstrual fluid.
Physiology
of Lactation: Breast-milk is formed out of ‘Rasa
Dhātu’ (Ca. Ci. 15/17). The essential nutrient fraction of ‘Rasa Dhātu’, enters
the breasts from the entire body and it is known as ‘Stanya’ (Su. Ni. 10/18).
Development
of Breasts: Ducts in the breast tissue of
non-pregnant women are narrow and are constricted. During pregnancy and after
delivery they get dilated as a natural phenomenon (Su. Ni. 10/16-17).
Various
Stimuli for Milk Letdown: Breast-milk is originally formed
from the essential fraction of food. It is ejected out of breasts because of
touch, sight and even because of mere remembrance of the baby. Uninterrupted
love of mother towards her baby is the cause of its flow (Su. Ni. 10/12-13).
Emotions, touch or even sight of the baby cause the hypothalamus of mother to
release oxytocin stored in the posterior pituitary. This causes the
myo-epithelial cells surrounding the glandular apparatus to contract and exert
a squeezing effect, thus allowing the milk to flow.
Urinary
System
The
abode of urine called ‘Mūtrāśaya’ supports the wastes of the body and is one of
the very important vital structures in the body. Minute ‘Nādīs’ (specialized
structures meantfor transportation) arising from the large intestine, carry the
urine continuously and contribute in the urine formation. This process is just
similar to the manner in which many small tributaries and rivers contribute
their water to the ocean. Openings of these ‘Nādīs’ cannot be traced out
because of their minuteness and huge number. Because of this urine, carried by
these ‘Nādīs’ from the proximity of stomach, ‘Basti’ (urinary bladder) gets
filled up continuously throughout the day and night through the process of
filtration. This process is similar to the fashion in which a new earthen pot
kept immersed in the water up to its neck gets filled up (by the water) after
some time through its sides (Su. Ni. 3/20-24). ‘Mūtrāśaya’ in the above
reference has been told to be very vital, and therefore, definitely is
indicative of kidneys, from a functional point of view. Suśruta probably knew
the role of kidneys in the formation
of urine. He probably also had observed that there exists some relationship between
water intake and urine formation. The fact that increased water intake results
in increased urinary output must have been the reason for this observation.
Also, decrease in the urinary output observed in the persons suffering from
diarrhea or vomiting might have been another reason. So, he proposed the
existence of invisible minute channels connecting GIT and urinary tract. This
prediction is not totally wrong because cardiovascular system definitely
connects both these systems. Water is absorbed from the gut into the venous circulation
and this is carried to the kidneys through the arterial system. Also, the
capillaries at Gut and glomerulus are definitely microscopic. The example of
mud pot in the above explanation indicates the role of filtration played by the
kidneys in the formation of urine. Thousands of ‘Nādīs’ taking part in the
process of filtration may stand for nephrons from a functional point of view.
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Kishor
Patwardhan, Concepts of Human Physiology in Ayurveda, in
‘Sowarigpa and
Ayurveda’,
published by Central Institute of Higher Tibetan Studies, Sarnath, Varanasi.
Samyak
Vak Series-14, Editor: Pabitra Kumar Roy (2008), Page No.53 to 73. ISBN:
978-81-
87127-76-5